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Saxena AR, Frias JP, Brown LS, et al

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Brigant, B., Metzinger-Le Meuth, V., Rochette, J

Headaches occasionally occur, particularly during initial use periods

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While C-reactive protein (CRP) is the most established systemic inflammatory CV risk marker, recent data indicate that inflammatory markers in vascular tissue [matrix metalloproteinases (MMP), osteopontin (OPN), and cathepsin D] may be more specific measures of plaque instability (239)