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Part of the carnitine can be produced endogenously, from lysine and methionine mainly by the liver and kidneys

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The combination of these three hormones results in a weight loss effect that surpasses that achieved by individual or dual agonists, making it a cornerstone in the therapeutic approach to MASLD ( 3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD