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511 However, most of the Tau protein-targeting therapies tested to date have been immunotherapies that can target Tau proteins intracellularly and/or extracellularly, but targeting extracellularly alone is unlikely to be effective, 512 and no Tau-targeting therapies have yet to show definitive clinical efficacy in preclinical or early-stage AD

With dose reduction, the timeline is not well documented but would be expected to fall somewhere between discontinuation and continued use

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[288] Chromatographic methods specific for amphetamine are employed to prevent false positive results