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(PubMed) Smith WA, Fry AC, Tschume LC, Bloomer RJ

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Ma and Farny (2023), senescence phenotypes in post-mitotic neurons cellular senescence are pronounced in enhanced activity of senescence-associated beta-galactosidase (SA--gal), cell cycle arrest [P53-P21 pathway and P16 pathway integrate to RB (retinoblastoma) hypophosphorylation], DNA damage, elevated RB hypophosphorylation, SASPs, and also senescence-associated heterochromatic foci (SAHFs), promoting cell cycle arrest (Ma and Farny, 2023

The decision-making process should take into account the availability of dialysis equipment and/or staff, the diagnosis and overall condition of the patient, the trend in serum ammonia levels, the response to nitrogen-scavenger therapy and the age and body weight of the patient

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