A lower-concentration build (2.5 mg/mL) spreads the dose across more units, so a one- or two-unit error is proportionally smaller at the cost of multi-fill draws later
uses a structured and science-backed method to manage microdosing
Endpoints As this is an exploratory trial, we will set three primary endpoints: (1) resolution rate from the baseline of NASH (defined by the NASH CRN as no more than mild residual inflammatory cells [score of 0 or 1] and no hepatocyte ballooning [score of 0]) without the worsening of liver fibrosis, with worsening defined as an increase of one stage or more on the Kleiner fibrosis classification scale [34]) after 52 weeks of intervention
Follow-Up Care and Monitoring Regular Monitoring: Adjustments to the dosage or treatment plan may be made based on the patients progress
Semaglutide (Wegovy/Ozempic) activates only GLP-1 and produces roughly 15% weight loss at 68 weeks
Each shipment carries an end-to-end tracking number, requires a signature on delivery, and ships in a thermally protected package sized to the route's seasonal temperature profile and transit window