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In the context of therapeutic response and resistance, accumulating evidence indicates that ROS contribute to the maintenance and reinforcement of resistance to platinum-based chemotherapy through adaptive mechanisms such as activation of the DNA damage response (ATR-Chk1), remodeling of ROS-regulated phosphorylation networks (e.g., CAMK2G-ITPKB), alterations in mitochondrial dynamics, and loss of MAPK regulators such as MKP3
2.5mg weekly for four weeks, then escalate
[Abstract]2026 Mar:352:151224
The threshold question for bio-better development is straightforward in theory and brutal in practice: does the modification produce an improvement that patients and physicians actually care about
"Ik krijg heel veel reacties van lezers die willen weten waar ik het haal, maar dat vertel ik niet
Open Access J Urol (2011) 3:1337
