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Redox-buffering capacity introduces an additional layer of heterogeneity

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Vitamin C at high doses accumulates in neutrophils and supports their chemotaxis, phagocytosis, and microbial killing capacity

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Slower Onset: Effects may take longer to notice, especially in people with severe depletion

There is one Phase I trial registered as NCT02637284 in 2015, intended to enrol forty-two participants, which was subsequently cancelled with no published results [7]