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Why Its Important: This phased approach is essential to help your body acclimate to the medication while minimizing potential side effects like nausea
There are other factors, like cost, availability, and side effects, which make patients seek better options
The SELECT trial, published in the New England Journal of Medicine in 2023, showed that semaglutide reduced major adverse cardiovascular events by 20% in patients with obesity and established cardiovascular disease
For these reasons, the current view of depression as an exclusively neurological disorder was expanded to consider it a systemic disease, given that depression involves the impairment of the hypothalamicpituitaryadrenal (HPA) axis, immune dysregulation, and disturbance of the gut-brain axis (Maes et al., 2011
While GLP-1s help reduce hunger and regulate metabolic signals, optimal results often come from pairing treatment with healthy lifestyle changes
Uneven skin tone, hyperpigmentation, dullness, oxidative stress from environmental exposure, and patients who want antioxidant support that works systemically
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