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Additional anti-diabetic medication is defined as other anti-diabetic medication that is initiated (all trials) or intensified by a dose increase of greater than 20% (PIONEER 2 to 5, and 8 only) during the planned treatment period as an add-on to treatment or initiated after premature discontinuation of treatment

[4] Important interactions and precautions with orlistat include: Orlistat is contraindicated with ciclosporin and must not be taken alongside it

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(2011) 170:e10515

This evidence underscores Semaglutides potential as a transformative solution for individuals grappling with obesity in Twin Falls