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Early podocyte injury, characterized by their effacement and detachment, compromises the filtration barrier integrity and contributes to albuminuria and subsequent glomerulosclerosis [1,19]

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This includes injectable options like semaglutide, known as Wegovy, which has shown an average body weight loss of 14.9% in clinical trials

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8 L cells in the gastrointestinal tract sense the presence of nutrients in the gut lumen during feeding and secrete GLP-1 to act on multiple tissues, including the pancreas, intestines, and brain

In propensity-matched analyses, semaglutide treatment was associated with lower rates of several cardiovascular outcomes than treatment with metformin, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter 2 (SGLT2) inhibitors