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Key molecular mechanisms include ROS-mediated MAPK phosphorylation [375], triggering NLRP3 inflammasome assembly [376], oxidative modification of NF-B inhibitor proteins leading to their nuclear translocation [377], and induction of mitochondrial DNA mutations [378]
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Nutrients 15, 2100
found that Exos from hemeified bone marrow MSCs (HO-1/BMSCs) effectively reduced hepatocyte ferroptosis by delivering miR-124-3p, which led to a significant decrease in the iron homeostasis factor, prostate six transmembrane epithelial antigen 3 [168]
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This is of particular importance since both proteins and RNA are accumulated in the seeds embryo and used in the first stages of germination (Bailly 2019
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