Intracellular GSH levels and the expression of antioxidant enzymes (NRF2, GPX4 and SOD1) were evaluated in tumor tissues in 51 patients receiving neoadjuvant chemotherapy
Oxidative stress, characterized by the excessive accumulation of reactive oxygen species (ROS) [34], can compromise mitochondrial membrane integrity [14], leading to increased permeability and the release of pro-apoptotic factors such as cytochrome c (CytC) into the cytoplasm [35]
doi: 10.1016/j.vph.2015.03.005 48 InoueKSakanoNOginoKSatoYWangDHKuboMet al
We suggest regular blood tests to check: Serum Vitamin B12 levels Methylmalonic acid (MMA) and homocysteine levels Complete Blood Count (CBC) to monitor for signs of anemia These results help us adjust the dose
K.Menezes-BenaventeL.GalvoV
Reconstitute a 5 mg vial with 2 mL bacteriostatic water (so 0.1 mL = 250 mcg), refrigerate, and inject at the same time daily for consistency