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Structural studies describe coordination through the imidazole nitrogen of the histidine residue together with the terminal amine and an adjacent amide nitrogen, forming a stable square-planar copper complex

Figure 2 Ferroptosis Ferroptosis is a novel form of programmed cell death, which is different from apoptosis, pyroptosis and autophagy in morphology and biochemistry

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4 Treatment DKD is a chronic complication of diabetes, improvements in glycemia control and blood pressure management by blocking the RAAS, currently available therapies could not be able to prevent progression to ESRD completely