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Among the new agents, GLP-1RAs are the most promising

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2.3 Transmembrane domain (TMD) iGluRs are members of the pore-loop superfamily of tetrameric ion channels, sharing structural homology with potassium channels, voltage-gated sodium and calcium channels, cyclic nucleotide-gated (CNG) channels, and transient receptor potential (TRP) channels

However, patches face significant challenges with peptide delivery due to the large molecular size of GLP-1 analogues

Ghergurovich, J