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The transition from phentermine to GLP-1 is well-established in clinical practice, and patients who responded well to appetite suppression on phentermine typically respond even better to GLP-1 medications

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However, the improved metabolic health and reduced body weight often normalize cortisol levels that were elevated due to obesity

However, three safety considerations matter: (1) L-carnitine may lower blood sugar in susceptible individuals, potentially amplifying tirzepatide's glucose-lowering effect and requiring dose monitoring

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Wegovy is the brand name for semaglutide 2.4 mg, a prescription medicine licensed in the UK for weight management in adults with obesity (BMI 30 kg/m) or those who are overweight (BMI 27 kg/m) with at least one weight-related comorbidity