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Choline is the major precursor of betaine, and it is used by the kidneys to maintain water balance and by the liver as a source of methyl-groups for methionine formation

Due to this risk, any medication that needs diluting for a newborn should be prepared with preservative-free sterile water

Metformin and B-12 Deficiency August 02, 2022 If you take metformin for diabetes, be aware that you are at risk for vitamin B-12 deficiency

[PMID: 20388954] PubMed record related to this compound for laboratory literature review

However, your liver can store vitamin B 12 for up to five years, so it's rare for diet to cause this anemia