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Some cell-types are much less sensitive to doxorubicin-induced GSH depletion
Recent studies suggest that cancer cells are under increased oxidative stress caused by oncogenic transformation, leading to metabolic alterations that result in ROS production 56
Note: Published safety data for TB-500 specifically is limitedmost evidence comes from Thymosin Beta-4 studies
Even a tiny change of intracellular pH caused growth attenuation
Figure 4 generally illustrates where we are headed and immediately makes apparent that NAPQI-induced hepatocyte necrosis centers on mitochondrial events
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