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For a more comprehensive discussion on this topic, please see Acidity and Basicity by professor William Reusch, Michigan State University
doi:10.1111/j.1365-2133.2009.09216.x
TPSA (topological polar surface area) is one of the most commonly used molecular descriptors in medicinal chemistry for predicting properties such as membrane permeability, transporter-mediated efflux, oral absorption, and CNS penetration
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Additionally, alpha-lipoic acid is a powerful antioxidant that can help to regenerate vitamins C and E, and maintain the redox balance in cells
Improving dependability in science: a critique on the psychometric qualities of the HiTOP psychosis superspectrum
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