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The activation of the JAK/STAT signalling cascade by IFN- drives microglia toward a proinflammatory M1 state, thereby accelerating neuronal damage, particularly in inflammatory environments enriched with cytokines such as TNF- and IL-1 [186, 198]

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K-F rings show up in about 97 percent of people with Wilsons disease

In adults, insomnia also correlates with severity of ADHD symptoms, highlighting the importance of reducing the overall impact of insomnia when deciding between treatments (Sangal et al., 2006

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