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Research has indicated that metformin treatment may lead to improvements in hormonal imbalances commonly associated with conditions such as PCOS by enhancing insulin sensitivity and indirectly decreasing biochemical hyperandrogenism

Interestingly, while this study discovered that CHAC1/BOTCH-mediated regulation of GSH levels controls development, other studies suggest its developmental role is primarily based on the inhibition of NOTCH1 signaling (Yadav et al., 2019)

These effects often diminish as the body adjusts to the medication

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