That increased pressure and prolonged acid exposure cause reflux in 1015% of patients, especially during dose increases
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As the dose increases over time, your bodys receptor activation strengthens, which leads to sustained appetite suppression and, in turn, fewer calories consumed
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For some patients, a step-down option to a lower-burden oral GLP-1 is useful, either short-term to bridge the transition, or as a lighter form of long-term support if and when it is clinically appropriate