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Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways

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10.1016/j.exer.2015.04.016 75 Medvidovic-GrubisicM.StambolijaV.KolencD.KatancicJ.MurselovicT.Plestina-BorjanI.et al (2017)

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1 In terms of lifestyle interventions, the ADA guidelines provide recommendations for dietary intervention and exercise patterns that promote a successful weight-loss plan

With that Ill note this final slide showing the plan for phase 2b with monthly titration, then going to a once monthly dosing scheme