Regulatory and commercial factors rather than safety concerns explain this limitation
The levels of glutathione depend on the mutation in question, and nrc1 , cad2-1 , pad2-1 and zir1 , which are affected in GSH1 show glutathione levels that range from 45 to 15% of normal levels 50,51,54,68
Importantly, folic acid should not be given alone before B12 deficiency is excluded or treated, as this can mask anaemia while allowing neurological damage to progress
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