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Gastric bypass, in particular, can often reverse type 2 diabetes and gastric reflux disease

I have also included oral folate supplements, probiotics and have expanded my diet (but still excluding caffeine, alcohol and sugar)

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Alternatively, trial a 4pm administration window: late enough to avoid morning jitteriness but early enough that Tmax (78pm) precedes typical sleep onset

[1] For example, if a 2 mL dose (full 200 mg thiamine, 200 mg niacinamide) is to be given IV, a nurse might mix it into 50 mL of saline and infuse over 15-30 minutes

Many studies have been small, of short duration, or focused on specific patient populations