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local-acting gastrointestinal peptides, where therapeutic effects are exerted within the gut lumen, represent a fundamentally different problem and are not addressed here

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No side effects except fatigue for the first week or so

indicated that GLP-1RAs treatment might increase the risk of thyroid cancer, with the risk demonstrating an upward trend with prolonged usage of the medication (13 years and longer) [4]

Continuous dosing without a break blunts receptor sensitivity and reduces the efficacy of subsequent cycles

At 2 mg doses, results approached those seen with Wegovy, though slightly lower on average