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Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis

Generation of T4 knockouts using TALEN We used TALENs to disrupt the T4 gene, designing a spacer nearby the ATG start codon of T4 to generate a frame shift mutation and loss of T4 function

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Long-term use of medications like proton pump inhibitors (PPIs) and metformin[16], which can reduce B12 absorption