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6,15 This review summarizes recent advances in the pathophysiology of DN, discusses current diagnostic and therapeutic strategies, and highlights potential future directions in managing this debilitating condition

Acc Chem Res 14:393400 Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

Treatment plans can be made to meet these specific needs

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Inorg Chem 63(29):1322313230