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The cytosolic GST enzymes comprise the largest family and based upon amino acid sequences and substrate specificities this family has been divided into seven subclasses identified as alpha (, A), mu (, M), omega (, O), pi (, P), sigma (, S), theta (, T), and zeta (, Z)

Studies have demonstrated that gut microbiota influence host mental health through multiple mechanisms, including neurotransmitter production, immune system modulation, and regulation of intestinal barrier function [487, 488]

It has undergone numerous human clinical trials (Phase I/II) but has not pursued further regulatory development

doi: 10.1155/2013/938751

This does not invalidate the findings, but it means the evidence base is not yet at the level of FDA-approved pharmaceuticals

A 15-residue fragment of this parent protein retained much of the biological activity observed in early experiments, and that fragment is the molecule sold here as BPC-157