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Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

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290,291,292 Accumulating macrophages release cytokines and chemokines, including IL-1, IL-6, chemokine ligand 2 (CCL2), and TNF-, intensifying the inflammatory environment and aggravating nerve damage

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62 In this context, our results support a model in which Trim37 -deficient PGCs exit the germline program and enter an aberrant somatic-like state marked by partial and heterogeneous activation of multiple somatic gene programs, rather than bona fide lineage-restricted transdifferentiation

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