Blood chemistry panels showed no hepatotoxicity (ALT, AST, bilirubin all within normal limits), no nephrotoxicity (creatinine, BUN unchanged), and no hematologic changes
Gomez-Pinilla 2007
Dabrafenib treatment significantly upregulated the expression of Axl receptor tyrosine kinase (Axl) in the spinal cord tissues of EAE mice, increased the expression of System Xc , GPX4, and Ferritin, and decreased the expression of CD71, ACSL4, and POR
Initially conceptualized as a therapeutic for neurodegenerative disorders such as Alzheimers and Parkinsons disease, its primary mechanism of action involves high-affinity binding to hepatocyte growth factor (HGF) and its cognate receptor c-Met
Decreased L-carnitine transport in mechanically overloaded rat hearts
Thymosin Alpha-1 (T1) is an immune regulator that enhances T-cell function and reduces inflammatory cytokines