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PROTAC degraders 245 and 246 selectively target HMGCR, a key enzyme in cholesterol biosynthesis, achieving efficient degradation in preclinical models
Its also pursuing outcomes-based reimbursement tied to sustained metabolic and behavioral metrics, positioning itself as primary care for metabolic health, not a weight-loss brand
Muscle tone starts disappearing despite staying active
However, future studies are required to primarily investigate the effect of GLP-1 RA penetration of the CNS in persons with PD [29]
This is about strategy
Each approaches GLP-1 support differently, and understanding these alternatives helps contextualize where Pendulum sits in the broader market
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