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Furthermore, TNF- suppresses osteogenesis by upregulating Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2, which cause the RUNX2 protein to be ubiquitinated and degraded by proteasomes (77)
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Local delivery is preferable as it achieves the target site at the same concentration as it was prepared directly without passing through all the body barriers via the bloodstream and without losing biopolymer molecules
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