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Some researchers extend to 8 weeks for more severe cases

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The most comprehensive review to date, published in JAAOS Global Research & Reviews , reached the same conclusion: Although preclinical studies are promising, there is a current lack of clinical trials (Rahman et al., 2026)

Adverse Effect Profile and Safety The most common adverse effects include gastrointestinal intolerance (nausea, vomiting, diarrhea), transient fatigue, and early satiety

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