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For weight management indications, prescribing guidelines generally require a BMI of 30 or above, or 27 or above with at least one comorbidity such as type-2 diabetes, hypertension, dyslipidaemia, or obstructive sleep apnoea
Adherence to treatment: Oral semaglutide should be taken daily in the morning with up to 4 ounces of water, at least 30 minutes before foods, liquids, or other medications
Of significance to appetite control, this effect is enhanced with co-administration of leptin
Early retinal pathological changes include the activation of retinal glial cells, with the most significant being the activation of Mller cells
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The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation
