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Giustarini, et al., J

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Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term

Vitamin D receptor prevents tumour development by regulating the Wnt/-catenin signalling pathway in human colorectal cancer