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All investigated ECAR parameters revealed no significant differences between unstimulated and LPS stimulated PBMC

They found that at the highest dosage of 4.8 mg survodutide weekly, study participants lost 14.9% of their body weight in comparison with a placebo group (2.8% weight loss) [122]

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Together, the enrichment of AP2 motifs at TRIM28-occupied loci, the physical interaction between TRIM37 and AP2, and their genomic co-occupancy support a model in which AP2 may cooperate with, or help stabilize, the TRIM37TRIM28 repressor complex at a subset of somatic gene loci