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Treatment of Drosophila flies with kynurenine pathway inhibitors and the NAD + precursors NR or NAM increased the lifespan of these animals, suggesting an advantage in combining different therapeutic strategies

An important nuance: while the trials did not publish detailed BMI-stratified results in their primary papers, the data consistently shows that higher baseline BMI correlates with greater absolute weight loss in kilograms, while lower baseline BMI correlates with greater percentage weight loss

The most intriguing finding from the Study was that Lexarias DehydraTECH-FTS composition, across all doses tested (asterisked below), demonstrated a predominantly higher apparent trend in brain biodistribution (evidenced as fluorescent signal intensity upon whole brain imaging) than the Rybelsus equivalent composition and all Study controls

DOI: 10.1007/s00401-018-1892-1 Epub 2018 Jul 25 29

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