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Data availability All sequencing data generated within this study have been uploaded to the NCBI Gene Expression Omnibus (GEO) and are available with accession codes: GSE289335 (RNA-seq), GSE289333 (ATAC-seq) and GSE289334 (CUT&Tag and CUT&RUN)

2024-GZL-RGZN-02012)

Acknowledgments We thank the Center of Metabolomics and Lipidomics in the National Protein Science Technology Center in Tsinghua University for LCMS/MS experiments

Assays for DHT, using 14C-testosterone/14C-4-androstenedione as substrates in gingival and oral periosteal fibroblast cell cultures in response to nicotine and glutathione would be a suitable index of redox status in a simulated model of selected parameters

The anti-inflammatory properties of MSM are well documented by scientific research

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