he isolated exendin-4, a peptide from the Gila monsters venom, which is structurally similar to human GLP-1 but more stable
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This is responsible for making people tired and weak
Curious about what we know about GLP-1s so far
Mechanistically, this was associated with increased expression/internalization of VEGFR2 and activation of downstream Akt-eNOS signaling (Hsieh 2017)
Moreover, GLP-1 and its analogs have shown positive effects in kidney protection, neuroprotection, and lipid metabolism regulation, and they hold promise in treating conditions like non-alcoholic steatohepatitis (NASH) and Alzheimer's disease