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It has been observed that repeated doses of DCA resulted in loss of GSTZ1-1 protein and activity, probably due to post-translationally modifications of the enzyme 85
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Secondary outcome Random assignment to GLP-1 RA treatment resulted in a reduced risk of Pulmonary edema (RR 0.66, 95% CI 0.440.98, p = 0.04
It's not just poor circulation it could be B12-related nerve issues
The FDA approved versions are manufactured under strict quality systems that control potency, sterility, and impurities
PMID 12240528
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