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Considering the potential of secondary bile acids to increase L-cells and GLP-1 secretion by TGR5, TGR5 agonists are promising drug candidates for increasing L-cells and GLP-1 secretion [180, 181]
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Identifies post-translational modifications (PTMs) Enables detection of modifications such as oxidation or deamidation that can impact stability and biological activity
Additionally, Wegovy delays gastric emptying, which may affect the absorption of oral medications, particularly those with a narrow therapeutic index (such as warfarin, requiring INR monitoring)
10.1186/s12986-015-0051-0 18
