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It is entirely possible that the slight rise in optic nerve issues reflects the underlying, advanced vascular damage or high baseline cardiovascular strains already present in patients who require these stronger medications, rather than a direct toxic effect of the drug molecules themselves

It keeps that separate from the semaglutide evidence base

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Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery

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