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Among the main inflammatory mediators, CRP plays a crucial role in atherogenesis by promoting complement activation, enhancing macrophage lipid uptake, stimulating pro-inflammatory cytokine release, inducing monocyte tissue factor expression, impairing endothelial function, and inhibiting nitric oxide production, further aggravating vascular injury (Shrivastava et al
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12 Most clinical studies assessing cardiovascular, cognitive, metabolic, or anti-inflammatory outcomes use daily ACN intakes ranging from tens of milligrams to several hundred milligrams, depending on the food or extract used
Additionally, the R152H mutation in GPX4 is involved in the development of Sedaghatian-type spinal metaphyseal dysplasia, a rare and fatal disease in newborn babies