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Yes, higher doses temporarily saturate renal clearance capacity, extending plasma half-life from the standard 68 hours to 911 hours at doses above 35mg
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doi: 10.1634/stemcells.22-4-625 11 WoodburyDSchwarzEJProckopDJBlackIB
It is to say that muscle pain on tirzepatide is almost always addressable, almost always reversible, and almost never a reason to abandon therapy that is otherwise working
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