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Those with moderate to severe non-proliferative diabetic retinopathy or proliferative disease at baseline may experience progression, particularly during the initial months of treatment when glycaemic control improves rapidly

Arch Biochem Biophys 319:128132 Hasan NM, Longacre MJ, Stoker SW et al (2008) Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase

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