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Abstract Background Heart failure (HF) is a major cardiovascular complication of type 2 diabetes mellitus (T2DM)

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First developed in the 1980s, research studies with modGRF have shown it to improve muscle repair and growth, accelerate wound healing, strengthen bones, increase fat burning, and improve metabolism

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Additionally, it enhanced the abundance of important intestinal microbial genera like Bacteroidetes , Akkermansia , and Prevotella , while simultaneously lowering the levels of Escherichia and Salmonella genera (65, 66)