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In the last decade, significant new data have accumulated lending support for an underlying, early cytodegenerative process of unknown nature that exhibits remarkable similarities to other neurodegenerative disorders

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The Takeaway few patients are being prescribed these life-saving drugs for diabetes management and reduced cardiovascular risk , possibly due to uncertainties of dosing, lack of knowledge of the CVOTs, clinical inertia, high costs, and tolerability

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Cons: Major surgery, long-term nutritional requirements, higher initial risk