Synergistic effects of PRIMA-1(Met) (APR-246) and 5-azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia
By stimulating endogenous glucagon secretion, protein could be a useful backup plan if the AID higher temporary targets were not implemented well in advance of activity and circulating insulin was elevated
Not recommended for children under 3 years old, pregnant or breastfeeding women
Medicare Utilization of GLP-1s Rises with Broader Indications Beyond Obesity Since Medicare does not cover anti obesity drugs when prescribed solely for weight management, utilization of weight loss indicated GLP-1s historically lagged behind their use in commercial markets
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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results