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Produced by the L-cells in the intestine in response to food intake, GLP-1 acts as a master regulator of metabolic function

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Statement #3: strong recommendation, moderate quality evidence (1B) Ammonia should be measured in an emergency setting with results available in 60 minutes

For those who require maximal weight loss, such as people managing severe obesity alongside cardiovascular risk or obstructive sleep apnoea, injectable therapy may remain the medically preferred route