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GLP-1RAs reduce experimental atherosclerosis in genetically sensitised mouse models, findings associated with reduction of systemic and aortic inflammation [119, 120]

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In addition, drug discontinuation, diarrhoea, injection-site-related events, nausea, vomiting and genital infections were more likely to occur in combination therapy

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Another factor leading to muscle loss is rapid weight loss, which clinical trials show that people on semaglutide may experience